Phenotypic and genetic parameters of antibody and delayed-type hypersensitivity responses of lactating Holstein cows

Abstract

Breeding dairy cattle using diverse phenotypic markers has been suggested as a feasible approach to improve health and decrease the deleterious consequences of infectious diseases. Studies conducted in pigs have demonstrated the value of antibody (AMIR)- and cell (CMIR)-mediated immune responses as quantitative traits for improving immune responsiveness by selecting livestock using estimated breeding values (EBV) for immune response (IR) traits. Studies of cattle have tested the possibility of using IR traits as phenotypic markers to classify cows as high (HR), average (AR) and low (LR) responders. Information is scarce or unavailable about either genetic parameters of AMIR and CMIR or their phenotypic and genetic associations with production, conformation, fertility or health traits in lactating dairy cattle. The objectives of the current study were to evaluate phenotypic and genetic parameters of both AMIR and CMIR as quantitative immunological traits (n=6) in comparison with production, fertility and health traits in dairy cattle for their use in a selection index intended to improve bovine health. Results of this study showed significant AMIR and CMIR responses. Most phenotypic correlations between IR traits and production, health or fertility traits were not significant. The highest heritabilities (h2) were observed for delayed-type hypersensitivity (DTH) to killed Candida albicans whole cell (CaWC) at 48h (0.54) and AMIR day 14 (0.42). The highest genetic correlations were observed between AMIR 14 and AMIR 21 (0.99) and between DTH to CaWC 24h and DTH to CaWC 48h (0.93). Two important and significant sire EBV correlations were noted between AMIR and fat % (0.18), and between CMIR and protein % (−0.15). In conclusion, this study demonstrated that both AMIR and CMIR are heritable traits in cattle and could be considered for their inclusion in a selection index intended to improve health.