Phenotypes of occupational bronchial asthma: external respiration status and quality of life

Abstract

An analysis of external respiration indicators and quality of life of patients with different phenotypes of occupational asthma was carried out (according to the analysis of the results of the MOS SF-36 questionnaire). In the patients with all phenotypes of the disease, there was a decrease in forced expiratory parameters in all phenotypes of occupational bronchial asthma, as well as in indicators of both mental and physical health relative to the control group (p<0.001). Notably, the worst indicators of quality of life were demonstrated by the patients with the phenotype of occupational asthma with metabolic syndrome. The individuals in this group had the lowest average scores on 6 out of 8 questionnaire scales, and significant differences were confirmed on 5 scales: these are the scales of physical functioning, general health, vital activity, social functioning, and role functioning due to emotional state. The quality of life was least affected in the patients with non-allergic phenotype of occupational bronchial asthma: the results of this group turned out to be the best among the patients with all disease phenotypes on 5 scales, and the patients scored significantly the highest on 4 of these scales.