Abstract
We studied the input of genetic and metabolic factors (PON1 gene polymorphism — Q192RPON1 genotype and glucolypotoxicity, respectively) to formation of enzyme functional characteristics in Type 2 diabetic patients (n = 31). Phenotyping of 79 blood samples was done by using PON1 rates of hydrolysis is of paraoxon (POase activity) and diazoxon (DZOase activity). POase activity was generally lower in diabetics than in control subjects. It was also found that against the background of conservation a determinant role of Q192RPON1 genotype for its phenotype the modulating impact of metabolic disturbances (a namely significant decrease in POase activity) was verified only in patients with QR genotype, which have been characterized significant more higher POase activity vs QQ genotype.On the other hand, there were diagnosed more pronounced hormonal-metabolic disturbances related to insulin resistance and oxidative stress in QQ homozygotes vs QR heterozygotes (increase in circulating leptin levels and decrease in erythocyte gluthathionperoxidase concentrations). We also confirmed that diazoxonase / paraoxonase activities index provides PON1 phenotype and genotype and an accurate inference of PON1 genotype. Both are important parameters for determining an individual’s PON1 status in Ukrainian Type 2 diabetes population.
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