Abstract
The results of modern experimental and clinical studies, regarding mutual influence of injuries on each other in case polytrauma, are presented in the review. Multiple severe injuries cause the phenomenon of their mutual aggravation, that is, the correlation of pathophysiological processes with worsening of patient’s status of health, growth of risk for development of complications and lethal outcome. Craniocerebral trauma, severe thoracic and abdominal injuries, long and pelvic bone fractures are the most significant in formation of this phenomenon. Mechanisms for realization of mutual aggravation of injuries include shock and hemorrhage, coagulopathy, systemic inflammatory reaction and posttraumatic complications. Mutual influence of injuries is to be taken into account for prediction and prevention of complications, development of pathogenetic methods of therapy and optimization of surgical tactics in treatment of polytrauma.
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