Phenolic derivatives with cytotoxic activities from the roots of Fallopia multiflora var. ciliinervis

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Fourteen phenolic derivatives including two new compounds (1, 2), one new natural product (10) and eleven known ones (3 - 9 and 11–14) were obtained from the roots of Fallopia multiflora var. ciliinervis. The structures were determined using IR, MS, 1D and 2 D NMR spectroscopy and the absolute configuration of the new structure (2) was deduced by ECD experiments. All of the isolated compounds were assayed for their cytotoxic activities against three tumor cell lines (A549, HCT116 and SW620) and the results showed that compounds 12－14 showed cytotoxicities against A549 cells while compounds 10 and 11 showed cytotoxicities against SW620 cells. • Two new compounds (1−2) and one new natural product (3) were isolated from the roots of Fallopia multiflora var. ciliinervis. • The absolute configuration of the compound 2 was elucidated by ECD experiments. • Compound 11 showed moderate activities against SW620 cells.