Abstract
Dipteryx alata Vogel is a native fruit from Brazil, which has been poorly investigated concerning its phenolic composition and the biological effects of its pulp + peel. Thus, in this study we evaluated the antioxidant activity and total phenolic content of the D. alata pulp + peel extracts obtained with different solvents, as well as determined the phenolic compounds by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis. In addition, cytotoxic effects of D. alata pulp + peel extract on non-tumor and cancer cell lines were investigated for the first time. The results showed that phenolic compounds can be efficiently extracted from pulp + peel of D. alata by organic solvent-water mixtures as an extraction system. The developed UHPLC-MS/MS method allowed the quantification of eighteen phenolic compounds in D. alata pulp + peel extract for the first time, which luteolin and trans-cinnamic acid were predominant. In addition, D. alata pulp + peel extract exhibited better cytotoxity against SiHa and C33A cervical cancer cell lines, while weak cytotoxicity was noticed against non-tumor HaCaT and L929 cell lines, pointing out its safety and providing preliminary evidence of its anticancer potential. Our findings indicate that D. alata pulp + peel can be explored as a natural source of phenolic compounds with promising antioxidant and cytotoxic properties.
Highlights
In the last decades, the health-promoting effects of fruits have attracted extensive attention from scientists worldwide
This study provides information on the total phenolic content (TPC), antioxidant activity by DPPH and ORAC assays, phenolic composition and cytotoxic effects on non-tumor and cancer cell lines for D. alata pulp + peel extracts
The results showed that antioxidant compounds, especially phenolic compounds, can be efficiently extracted from pulp + peel of D. alata by using Ultrasound-assisted extraction (UAE) and organic solvent-water mixtures as an extraction system
Summary
The health-promoting effects of fruits have attracted extensive attention from scientists worldwide. The present study aimed to evaluate the antioxidant activity and TPC of the D. alata pulp + peel extracts obtained with different solvents, as well as to determine the phenolic compounds by ultrahigh performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) analysis.
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