Abstract
Background Phase-locked bursting and oscillations in low frequency bands between the subthalamic nucleus (STN) and the globus pallidus (GP) are key features of the pathophysiology of Parkinson's disease (PD). These dynamics may reflect susceptibility of the basal ganglia (BG) to entrainment with cortical oscillations or could also be a consequence of enhanced reciprocal STN-GP coupling under conditions of dopamine depletion. Phase response analysis is an efficient method of characterizing the tendency of single neurons to entrain to periodic input, and to predict the tendency of connected networks to synchronize. A phase response curve (PRC) describes the dependency of shifts in spike timing that result from weak inputs on the timing of inputs within the ongoing inter-spike interval (ISI). If, independent of stimulus phase, a depolarizing input causes an advance of the next spike, the PRC will be composed purely of positive values (a Type I PRC). A Type II PRC contains both positive and negative regions, indicating that a depolarizing from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007 Toronto, Canada. 7–12 July 2007
Highlights
Phase-locked bursting and oscillations in low frequency bands between the subthalamic nucleus (STN) and the globus pallidus (GP) are key features of the pathophysiology of Parkinson's disease (PD)
A phase response curve (PRC) describes the dependency of shifts in spike timing that result from weak inputs on the timing of inputs within the ongoing inter-spike interval (ISI)
We found that larger stimuli caused increased outward K+ flow through the Ca++ activated SK channel, and hypothesized that large stimuli delivered to small distal compartments activate the high-voltage Ca++ channel (HVA) which in turn activates SK
Summary
Sixteenth Annual Computational Neuroscience Meeting: CNS*2007 William R Holmes Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1471-2202-8-S2-info.pdf
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