Phase Partitioning of influenza Virus Neuraminidase in a Model Membrane

Abstract

Today, more than ever, understanding the biophysics of viruses, specially enveloped viruses with spike transmembrane glycoproteins like SARS-CoV-2 and influenza seems imperative. From three transmembrane proteins of influenza virus i.e. neuraminidase (NA), hemagglutinin (HA), and the proton channel protein M2, the former is of most interest as it contains a bulky head which nominates it as a key player in the virus budding process due to its ability in generating lateral pressure. Recent reports suggest that localized protein-protein crowding can bend membranes and drive curvature and tubulation.