Phase-Amplitude Coupling Features Accurately Classify Multiple Sub-States Within a Seizure Episode.

Abstract

Epilepsy is frequently characterized by convulsive seizures, which are often followed by a postictal EEG suppression state (PGES). The ability to automatically detect and monitor seizure progression and postictal state can allow for early warning of seizure onset, timely intervention in seizures themselves, as well as identification of major complications in epilepsy such as status epilepticus and sudden unexpected death in epilepsy (SUDEP). To test whether it is possible to reliably differentiate these ictal and postictal states, we investigated 52 seizure records (both intracranial and scalp EEG) from 19 patients. Phase-amplitude cross-frequency coupling was calculated for each recording and used as an input to a convolutional neural network model, achieving the mean accuracy of 0.890.09 across all classes, with the worst class accuracy of 0.73 for one of the later ictal sub-states. When the trained model was applied to SUDEP patient data, it classified seizure recordings as primarily interictal and PGES-like state (70% and 26%, respectively), highlighting the fact that in SUDEP patients seizures primarily exist in postictal states and don't show the ictal sub-state evolution. These results suggest that using frequency coupling markers with a machine learning algorithm can reliably identify ictal and postictal sub-states, which can open up opportunities for novel monitoring and management approaches in epilepsy.