Abstract
Oxytocin-(1 -6)-hexapeptide amide and vasopressin-(1 -6)-hexapeptide amide had lower activities than the parent hormones on the isolated rat uterus and in the antidiuretic assay in hydrated rats; none of the analogues had pressor activity. Deamination of both rings increased uterotonic activity. The uterotonic effect of the analogues was blocked by N-carbamoyl-2-O-methyloxytocin, a competitive inhibitor of oxytocin, which proved their action to be specific. Mg 2+ did not potentiate the effect of the ring molecules on the isolated uterus.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call