Abstract
One gram of indanyl carbenicillin was administered orally to 20 volunteers with various degrees of renal insufficiency. Concentrations of carbenicillin in serum and urine of volunteers with mild renal insufficiency (creatinine clearance of 3384 ml/min) were similar to those of normal subjects. Concentrations in serum of those with more pronounced renal impairment were approximately twice normal. There was no measurable carbenicillin recovered from the urine of patients with severe renal insufficiency (creatinine clearance of less than 14 ml/min). Volunteers with moderate renal impairment (creatinine clearance of 17-22 ml/ min) had delayed excretion of carbenicillin with lower urinary concentrations. It was concluded that patients with mild to moderate renal insufficiency would excrete sufficient carbenicillin, following an oral 1-gram dose, to treat satisfactorily urinary-tract infections due to carbenicillin-sensitive organisms. However, it is doubtful that, even with multiple doses, adequate concentrations can be obtained in the urine of patients with marked renal insufficiency.
Published Version
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