Abstract
The pharmacological effects of Conus textile venom on the rabbit aorta, the guinea-pig left atria, vas deferens and ileum, and the mouse diaphragm were examined. The venom caused a marked, transient contraction of the ileum which was abolished by atropine and tetrodotoxin. The venom exhibited a positive inotropic effect on the left atria which was almost completely inhibited by verapamil. Activity on the ileum was retained after heating at 70°C for 1 hr, exposure to 1 N HCl or 1 N NaOH and incubation with proteases. Active material(s) in the venom passed through a UM2 filter, suggesting a molecular weight lower than 1000.
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