Abstract
A myotoxin purified from Conus magus venom elicited complete loss of contractile response of the mouse diaphragm to electrical stimulation followed by a gradual rise in the baseline, an increase in the contractile force of the guinea-pig left atria, a tonic contraction of the guinea-pig taenia caeci and powerful rhythmic contractions of the guinea-pig ileum and vas deferens. These excitatory effects of the toxin were blocked by treatment with tetrodotoxin, suggesting that these effects were due to an increase in Na + permeability of the cell membrane.
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