Abstract
The main objective of this study was to perform pharmacological evaluation of Stay-On Power Capsules in Rabbits (Non-Rodents) namely the aphrodisiac activity. The present investigation deals with Pharmacological Studies (Mating behaviour study, mating performance test, Hormonal analysis, Reproductive organ and spermal analysis) of Stay-On Power Capsules in Non-Rodents administered orally by gavage to Rabbits in accordance with the schedule Y of drugs and Cosmetic Act (2005). The acute toxicity study of Stay-On Power Capsules was done by up and down method. After the completion of acute toxicity studies, three different doses were selected for aphrodisiac activity such as 150, 300, and 600 mg/kg. Volume of oral administration was 1 ml/100 g of animals. Animals were randomly divided into five groups with six animals per group. Group I represented the control animals treated with normal water only; Groups II, III, and IV were treated with oral suspension of Stay-On Power Capsules at 18:00 h, at doses of 150, 300, and 600 mg/kg, respectively; and Group V served as a positive control treated with Sildenafil citrate of 5 mg/kg body weight. All the treatments were continued for 3 weeks only. A mating behaviour study revealed that continuous administration for 3 weeks, all the doses of Stay-On Power Capsules were able to significantly decrease mount and intromission latencies, and decrease ejaculatory latency and post ejaculatory interval when compared to vehicle control and standard drug treated Rabbits. It also resulted in a dose dependent increase in the mating performance and showed increasing ratio of testes body weight along with increase in sperm count as compared to the control group. Key Words: Stay-On Power Capsules, Pharmacological Studies, aphrodisiac activity, mating behaviour, mating performance
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