Pharmacological studies of feed additives (Sanguinarine and Saccharomyces cerevisiae) on growth performance, haematological and intestinal bacterial count with challenge test by Aeromonas hydrophila in Cyprinus carpio

Abstract

This study analyzed the effect of dietary supplementation of commercial product Sangrovit which containing the isoquinoline alkaloid sanguinarine by 500 gm/ton ration, and Saccharomyces cerevisiae (yeast probiotic) by 5 g/Kg on common carp (Cyprinus carpio) growth performance, hematological and gut microbiota with challenge test by Aeromonas hydrophila in Cyprinus carpio compared to the control group determined at 15 days intervals during the feeding trial. Each dietary treatment had two replicate aquaria. The results showed that during the period of experiment the using this feed additives showed slight significant increase in growth performance except in sanguinarine plus vitamins which showed high significant (P<0.05) increase specially at 45 days meanwhile all groups show non significant changes in Erythrogram and Leucogram except sanguinarine supplemented groups slightly increased. All groups showed significant (P<0.05) decrease in gut micobiota (total bacterial and coliform count) and also more resistance to challenge test with Aeromonas hydrophila. So these feed additives enhance the fish defense mechanism and elevates the resistance to fish to disease. According to our knowledge this study considers the first record on fish in Egypt.