Abstract
Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
Highlights
Medicinal plants are one of the most important sources of active substances with therapeutic potential and these are often used to cure a variety of diseases in humans [1,2]
In order to evaluate the pharmacological basis for a better understanding of the use of M. platyclada in folk medicine, the present study was designed to investigate the antinociceptive and anti-inflammatory effects of ethanol extract obtained from leaves using animal models
The phytochemical screening results of the ethanol extract showed the presence of different types of active constituents like flavonoids, terpenoids, sterols, coumarins, tannins, saponins and volatile oils
Summary
Medicinal plants are one of the most important sources of active substances with therapeutic potential and these are often used to cure a variety of diseases in humans [1,2]. The use of medicinal plants as anti-inflammatory and analgesic agents is a common practice and have been the target of recent studies [4,5]. The genus Muehlenbeckia is constituted by four species belonging to the family Polygonaceae. Plants of this genus, such as Muehlenbeckia platyclada M. platyclada inhibited the generation of superoxide anion and elastase released by human neutrophils, indicating anti-inflammatory activity [8]. In order to evaluate the pharmacological basis for a better understanding of the use of M. platyclada in folk medicine, the present study was designed to investigate the antinociceptive and anti-inflammatory effects of ethanol extract obtained from leaves using animal models
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