Abstract
Antinociceptive and anti-inflammatory activities of the ethanol extract from Annona muricata L. leaves were investigated in animal models. The extract delivered per oral route (p.o.) reduced the number of abdominal contortions by 14.42% (at a dose of 200 mg/kg) and 41.41% (400 mg/kg). Doses of 200 and 400 mg/kg (p.o) inhibited both phases of the time paw licking: first phase (23.67% and 45.02%) and the second phase (30.09% and 50.02%), respectively. The extract (p.o.) increased the reaction time on a hot plate at doses of 200 (30.77% and 37.04%) and 400 mg/kg (82.61% and 96.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by the ethanol extract (p.o.) at doses of 200 (23.16% and 29.33%) and 400 mg/kg (29.50% and 37.33%) after 3 to 4 h of application of carrageenan, respectively. Doses of 200 and 400 mg/kg (p.o.), administered 4 h before the carrageenan injection, reduced the exudate volume (29.25 and 45.74%) and leukocyte migration (18.19 and 27.95%) significantly. These results suggest that A. muricata can be an active source of substances with antinociceptive and anti-inflammatory activities.
Highlights
Annona muricata L. (Annonaceae), commonly known as soursop, is found from Central America toSouth America, including the North, Northeast and Southeast regions of Brazil [1,2]
Among the chemical constituents found in A. muricata, the alkaloids [4,5] and essential oils
Species of the Annonaceae family, including A. muricata, have been targeted for investigation due to appurtenant substances in the acetogenins class [8] that have been isolated from different parts of the plant [9]
Summary
Annona muricata L. (Annonaceae), commonly known as soursop, is found from Central America to. B, annonacin A, (2,4-trans)-isoannonacin, (2,4-cis)-isoannonacin [11], annomuricin C, muricatocin C, gigantetronenin [12], annomutacin, (2,4-trans)-10R-annonacin-A-one, (2,4-cis)-10R-annonacin-A-one [13], annopentocins A, B and C, cis- and trans-annomuricin-D-ones [14], annomuricine, muricapentocin [15], muricoreacin and murihexocin C [16] and annocatacin A and B [17] were identified in the leaves These acetogenins have cytotoxic properties against tumor cell lines [10,11,12,13,14,15,16,17]. A. muricata ethnomedicinal use, especially for inflammation, rheumatism and neuralgy, still lacks scientifically supported pharmacological and clinical validation In this sense, the aim of the present study was to investigate the antinociceptive and anti-inflammatory properties of the ethanol extract from A. muricata leaves using experimental animal models
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