Abstract
In the present study, the dry powdered bark of Erythrina fusca was extracted with methanol. It was subjected to peripheral analgesic study using the acetic acid-induced writhing test in mice model and it demonstrated significant analgesic activity. The methanol extract was partitioned into n-hexane, chloroform and water-soluble fractions. Primarily, the chloroform fraction of the methanol extract was subjected to various chromatographic techniques and four major metabolites, Lupinifolin (1), Lupinifolin-4’-methyl ether (2), Sandwicensin (3) and Licoagrocarpin (4) were purified. Molecular docking studies of 1-4 against cyclooxygenase-2 (COX-2) enzyme suggest that they may interact with COX-2 at different levels. The pharmacokinetic and biological parameters of 1-4 were also checked through in silico tool to understand their drug-likeliness. Bangladesh J. Bot. 53(2): 305-311, 2024 (June)
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