Abstract
Abstract The interaction between the steroidal neuromuscular blocking agent pancuronium bromide and two anaesthetic agents was investigated in cats. Thiopentone or halothane reduced the effective neuromuscular blocking dose of pancuronium bromide. Under the influence of these the block anaesthetics induced by pancuronium bromide remained reversible by neostigmine. Pancuronium bromide did not influence the EEG pattern produced by thiopentone anaesthesia, nor did it enhance the blood pressure depressing effect of the barbiturate. The hypotension occurring with halothane was unchanged when pancuronium bromide was administered although occasionally the neuromuscular blocking steroid appeared to counteract the hypotensive effect of halothane to a small extent. Pancuronium bromide blocked several circulatory responses caused by peripheral vagal stimulation, but did not influence similar responses due to injected acetylcholine; nor did it markedly inhibit the contractions of the gut induced by vagal stimulation.
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