Abstract
Five groups of 8 rats were treated with normal diet, diphenylhydantoin, dexamethasone, thyroxine (T 4) and phenobarbital respectively for 14 days. After this period plasma triiodothyronine (T 3), T 4 and reverse T 3 (rT 3) concentrations as well as the T 4 to T 3 converting activity in the liver homogenates were determined. Plasma T 3 was low after dexamethasone, T 4 and phenobarbital. Plasma T 4 was low after dexamethasone and elevated after T 4. rT 3 plasma concentrations were at the lower limit of detection in all groups. The converting activity in the liver homogenate was significantly increased after diphenylhydantoin and very much depressed after dexamethasone. These results support the concept that different drugs may influence the peripheral thyroid hormone metabolism, especially the T 4 to T 3 conversion. However other pathways might be affected also because plasma T 3 levels did not always reflect the converting activity in the liver.
Published Version
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