Abstract
Pharmacological evaluation of sustained release matrix tablets containing Vaccinium myrtillus leaf dry extract as an alpha-glucosidase inhibitory drug
Highlights
Diabetes mellitus type 2 (DMT2) is a chronic metabolic disorder that has spread worldwide, regardless of geographical location, population features and economic development level
highly palatable fat- and sugar-rich (HPFS) diet-induced metabolic syndrome resulted in persistent insulin resistance and glucose tolerance observed in all pathological animals
By all markers studied in this work the effectiveness of VMLDE matrix tablets in a hamster model of induced metabolic syndrome with persistent insulin resistance exceeded that one of pure extract
Summary
Diabetes mellitus type 2 (DMT2) is a chronic metabolic disorder that has spread worldwide, regardless of geographical location, population features and economic development level. The current approaches in DMT2 therapy include modification of lifestyle, obesity treatment and administration of oral hypoglycemic agents like biguanides, sulfonylureas, thiazolidinediones, alpha-glucosidase inhibitors, dipeptidyl peptidase-4 inhibitors, etc Despite such an abundance of antidiabetic medications the global situation with diabetes has not been improved so far. Natural polyphenols are known to have a low bioavailability and in the case of chlorogenic acid it is obviously related to its high absorption starting already in the stomach and followed by intensive metabolism in tissue cells and rapid elimination from the body [9, 10] Based on these considerations the formulation of sustained release matrix tablets containing V. myrtillus leaf dry extract has been developed. Taking into account the scientific evidence on α-glucosidase inhibitory activity of V. myrtillus leaf extracts and its phytochemical constituents [11, 12], we believe that matrix tablet formulation will contribute to the increasing release of the polyphenolic substances directly in the small intestine and improving the effectiveness of the hypoglycemic treatment
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