Formulation and evaluation of lamivudine sustained release tablet using okra mucilage

Narahari Palei,Jayaraman Rajangam,Santhosh Mamidi

doi:10.7324/japs.2016.60910

Abstract

Hepatitis in Bangladesh: Pattern and treatment OptionsMost. Nazma Parvin, Riaz Uddin, Sadia Afreen Chowdhury

Highlights

In recent years, plant gums and mucilages have evoked tremendous interest due to their diverse pharmaceutical applications such as diluents, binders, disintigrants in tablet, thickener in oral liquid, protective colloids in suspensions and gelling agent in gels (Singh et al, 2009; Ameena et al, 2010)
The slightly soluble behavior of Okra gum is useful in this formulation as the swellable and viscous dispersion represents a strong matrix polymeric system that is able to control the release of Lamivudine
Okra gum is known to have maximum viscosity at a neutral pH range, which helps in the retarding effect for the development of sustained release tablet

Summary

Introduction

Plant gums and mucilages have evoked tremendous interest due to their diverse pharmaceutical applications such as diluents, binders, disintigrants in tablet, thickener in oral liquid, protective colloids in suspensions and gelling agent in gels (Singh et al, 2009; Ameena et al, 2010). Polysaccharides are obtained from plants that could be applied in various pharmaceutical products. We have isolated and characterized Okra mucilage and evaluated its sustained-release properties employing Lamivudine as a model drug. Lamivudine has been used for the treatment of AIDS and chronic Hepatitis B. Treatment of AIDS using Lamivudine conventional formulations is shown adverse side effects resulting from accumulation of drug in multidose therapy, poor patient compliance, and high cost. Lamivudine sustained release formulation can overcome some of these problems (Moyle et al, 2007; Punna et al, 2003). The matrix tablets of Lamivudine were formulated using wet granulation method and evaluated for weight variation, swelling behavior, hardness, friability and in vitro drug release

Methods

Results

Conclusion