Pharmacological Correction of Experimental Acute Toxic Hepatitis

Abstract

The aim of study was to develop new methods of treatment of acute toxic hepatitis. To achieve this objective, the authors investigated dynamics of pathological changes in the hepatic tissue under acute intoxication followed by the pharmacological correction with sodium hypochlorite.Material and methods. The study included 45 male rats that were subjected to the experimental simulation of acute toxic hepatosis. Group 1 included intact animals; group 2 included animals that were intragastrically administered allyl alcohol resulting in acute toxic hepatosis; group 3 included rats with acute toxic hepatosis caused by allyl alcohol introduction that was corrected by sodium hypochlorite; group 4 included animals with acute toxic hepatosis corrected by essentiale N; group 5 included animals with acute toxic hepatosis corrected by the combined application of sodium hypochlorite and essentiale N. On the 6th day the animals were removed from the experiment with the followed histological examination of the hepatic tissue.Results. The introduction of allyl alcohol was accompanied by significant changes in hepatocytes expressed by dystrophic, necrotic processes and circulatory disorders of the hepatic lobules. Pharmacological correction by sodium hypochlorite, essential H, or their combination did not result in the complete histological recovery of hepatocytes; however, the degree of fatty degeneration decreased significantly under the influence of sodium hypochlorite or its combination with essentiale N.Conclusions. The application of sodium hypochlorite as a monotherapy or in combination with essential N in acute toxic hepatitis has allowed to relieve the severity of fatty liver disease. 0.03% solution of sodium hypochlorite can be effective as both - an independent method for treating acute toxic hepatitis, and in combination with other hepatoprotectors.