Abstract
<p class="Abstract"><em>Viola odorata</em> is traditionally used in the management of gastrointestinal, respiratory and vascular disorders. The present study was undertaken to validate its folkloric uses. The application of <em>V. odorata</em> to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions. Moreover, it also caused relaxation of K<sup>+ </sup>(80 mM)-induced contractions and shifted the Ca<sup>2+ </sup>concentration response curves toward right in isolated jejunum similar to verapamil (standard Ca<sup>2+ </sup>channel blocker), confirming Ca<sup>2+ </sup>channel blocking activity. <em>V. odorata</em> also caused relaxation of carbachol (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit tracheal preparations comparable to verapamil, reflecting that observed relaxant effect may be the outcome of anti-muscarinic and/or Ca<sup>2+ </sup>channel blocking activities. It also exerted relaxant effect on phenylephrine (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit aortic preparations thus providing rationale for its folkloric uses to treat diarrhea, asthma and hypertension.</p>
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