Abstract
Batrachotoxin, pumiliotoxin B, isodihydrohistrionicotoxin, pumiliotoxin C and gephyrotoxin represent five different classes of skin alkaloids from the dendrobatid poison dart frogs. In quinea pig ileum segments batrachotoxin and pumiliotoxin B caused rhythmic contractures which were prevented by tetrodotoxin. In quinea pig atria, batrachotoxin and pumiliotoxin B had positive inotropic and chronotropic effects, followed in the case of batrachotoxin by irregular arrhythmias and atrial arrest. Isodihydrohistrionicotoxin has no apparent effect in ileum or atrium, while gephyrotoxin was a potent muscarinic antagonist. In rat phrenic nerve-diaphragm, batrachotoxin blocked both direct and indirect-elicited twitch; pumiliotoxin B potentiated both direct and indirect-elicited twitch, isodihydrohistrionicotoxin blocked indirect-elicited twitch and gephyrotoxin had no apparent effect. Pumiliotoxin C had no apparent effect in any of the preparations.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call