Abstract

Indoles are amongst the most important class of heteroaromatics in organic chemistry, being generally found in biologically active natural products. Indole motifs have become noteworthy compounds because of their ample assortment of applications in medicine, synthetic chemistry, coordination chemistry, as well as in the field of industrial chemistry. Ethyl-3-oxo-3-{2-[(5-substituted-3- phenyl-1H-indol-2-yl) carbonyl] hydrazinyl} propanoates 5a-b were synthesized according to the literature method. These on further reaction with substituted- 2-hydroxy-3-formylquinolines 3a-e yielded 5-substituted-Nβ-(2-oxo-2H-pyrano [2, 3-b] quinoline-3-carbonyl)-3-phenyl-1H-indole- 2- carbohydrazide 6a-j. Spectral techniques were used to confirm the structures of the all synthesized compounds. All these compounds have been screened for their pharmacological activities such as anti-inflammatory and analgesic activities.

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