Abstract
The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin sodium intravenously over 1 min and placed on on-line HDF for 4 h starting at 60 min after the piperacillin infusion. Noncompartmental models were employed for estimation of the pharmacokinetic parameters, and intradialytic piperacillin clearance was calculated by the recovery method. The mean volume of distribution and the elimination half-life were 0.27 +/- 0.13 liter/kg (mean +/- standard deviation) and 1.1 +/- 0.6 h, respectively. The total body clearance of piperacillin was 0.19 +/- 0.08 liter/h/kg. Piperacillin clearance through on-line HDF was 0.11 +/- 0.06 liter/h/kg. The mean serum piperacillin concentration was 4.0 +/- 1.9 microg/ml at the end of the 4-h on-line HDF session. The concentration of infused piperacillin recovered in the dialysate was 527 +/- 236 mg (26.3% +/- 11.8%). We suggest the replacement of 500 mg of piperacillin after each on-line HDF session.
Highlights
The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF)
We studied the pharmacokinetics of piperacillin administered intravenously to five volunteers undergoing on-line HDF
During the 4-h on-line HDF, 527 Ϯ 236 mg (26.3% Ϯ 11.8%) of the piperacillin infused was recovered in the dialysate
Summary
The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). It is known to inhibit most of the clinically important members of the family Enterobacteriaceae, such as Escherichia coli, Enterobacter cloacae, and Proteus mirabilis, and approximately half of the isolates of Klebsiella pneumoniae It is four- to eightfold more active than carbenicillin at inhibiting Pseudomonas aeruginosa [7, 15]. This wide spectrum and potent antipseudomonal activity make piperacillin useful It is prescribed for the treatment of neutropenic fever in combination with tobramycin. (molecular mass, 516.5 Da) is large enough that its dialytic clearance would likely be influenced by the dialysis technique For these reasons, we studied the pharmacokinetics of piperacillin administered intravenously to five volunteers undergoing on-line HDF. The purpose of this study is twofold: (i) to characterize the pharmacokinetics and dialytic clearance of piperacillin by on-line HDF in otherwise healthy subjects with end-stage renal disease and (ii) to develop strategies for piperacillin dosing in those subjects placed on on-line HDF
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
