Abstract
The pharmacokinetics and tissue residues of moroxydine hydrochloride were studied in gibel carp at water temperature of 15 and 25°C. Samples (blood, skin, muscle, liver, and kidney) were collected over 10days after the treatment and analyzed by high-performance liquid chromatography with anultraviolet detector. The results indicated that the influence of water temperature on the metabolism of the drug was significant. The plasma concentration-time data of moroxydine hydrochloride conformed to single-compartment open model at the two water temperatures. There were higher absorption rate (t1/2ka ) and longer elimination half-lives (t1/2ke ) at 15°C (4.29 and 15.87h, respectively) compared with those at 25°C (3.02 and 4.22h, respectively). The maximum plasma concentration (Cmax ) and the time-point of maximum plasma concentration (Tp ) were 2.98 μg/mL and 10.35h at 15°C and 3.12 μg/mL and 4.03h at 25°C, respectively. The distribution volume (Vd /F) of moroxydine hydrochloride was estimated to be 4.55L/kg at 15°C and 2.89L/kg at 25°C. The total body clearance (CLb ) of moroxydine hydrochloride was determined to be 0.25 and 0.49L/(h·kg) at 15°C and 25°C, respectively; the areas under the concentration-time curve were 75.89 μg·h/mL at 15°C and 42.33 μg·h/mL at 25°C. The depletion of moroxydine hydrochloride in gibel carp was slower with a longer half-life period, especially at lower water temperature that was tested.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of veterinary pharmacology and therapeutics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.