Abstract
The objectives of this study were to formulate oral paclitaxel microemulsion and to compare the bioavailability of paclitaxel in the microemulsion formulation from the commercially available formulation. Paclitaxel microemulsion was formulated with much less amount of Cremophor as compared with to reduce severe adverse reactions produced by Cremophor . The area under the plasma concentration-time curve from 0 hr to 24 hr (), maximum plasma concentration (), and relative bioavailability of palcitaxel microemulsion were increased as compared with after oral administration. The time required to reach of palcitaxel microemulsion was significantly shorter than following oral administration. These results suggest the faster intestinal absorption and the enhanced oral bioavailability of paclitaxel in the microemulsion formulation.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call