Abstract
BackgroundFurosemide, a diuretic that acts on the loop of Henle, is commonly used to treat congestive heart failure in veterinary medicine. Some owners have difficulty in administering oral tablet medication to animal patients, which leads to noncompliance, especially during long-term administration. Oral disintegrating film (ODF) has the advantages of easy administration via a non-invasive route, rapid dissolution, and low suffocating risk. The objective of this study was to research the pharmacokinetic (PK) profiles and diuretic effect of furosemide after intravenous (IV), orally uncoated tablet (OUT), and newly developed ODF administration in healthy beagle dogs. In this study, a furosemide-loaded ODF (FS-ODF) formulation was developed and five beagle dogs were administered a single dose (2 mg/kg) of furosemide via each route using a cross-over design.ResultsThe most suitable film-forming agent was sodium alginate; thus, this was used to develop an ODF for easy drug administration. No significant differences were detected in the PK profiles between OUT and FS-ODF. In the blood profiles, the concentration of total protein was significantly increased compared to the baseline (0 h), whereas no significant difference was detected in the concentration of creatinine and hematocrit compared to the baseline. FS-ODF resulted in a similar hourly urinary output to OUT during the initial 2 h after administration. The urine specific gravity was significantly decreased compared to the baseline in each group. The peak times of urine electrolyte (sodium and chloride) excretion per hour were 1 h (IV), 2 h (OUT), and 2 h (FS-ODF).ConclusionsThese results suggest that the PK/PD of furosemide after administration of newly developed FS-ODF are similar to those of OUT in healthy dogs. Therefore, the ODF formulation has the benefits of ease and convenience, which would be helpful to owners of companion animals, such as small dogs (< 10 kg), for the management of congestive heart failure.
Highlights
Furosemide, a diuretic that acts on the loop of Henle, is commonly used to treat congestive heart failure in veterinary medicine
Koh et al BMC Veterinary Research (2021) 17:295. These results suggest that the PK/PD of furosemide after administration of newly developed FS-Oral disintegrating film (ODF) are similar to those of orally uncoated tablet (OUT) in healthy dogs
The ODF formulation has the benefits of ease and convenience, which would be helpful to owners of companion animals, such as small dogs (< 10 kg), for the management of congestive heart failure
Summary
Furosemide, a diuretic that acts on the loop of Henle, is commonly used to treat congestive heart failure in veterinary medicine. Furosemide, a diuretic commonly used in veterinary and human medicine, is recommended as first-line therapy in the management of congestive heart failure (CHF) [1, 2]. It is used in animals for the treatment of pulmonary edema, udder edema, hypercalciuric nephropathy, uremia, and hypertension. Furosemide decreases the absorption of electrolytes in the luminal surface of the thick ascending loop of Henle via the deactivation of the Na+-K+-2Cl− cotransporter This drug increases the renal excretion of sodium, potassium, chloride, and water [8]. Furosemide increases renin secretion, owing to its effects on the nephron, increases in sodium and water retention do not occur [8]
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