A Novel Self-Expandable, Radioactive Airway Stent Loaded with 125I-Exposed Seeds: A Feasibility and Safety Study in the Healthy Beagle Dogs

Abstract

PurposeThe purpose of this study was to investigate the feasibility and safety of a novel self-expandable, radioactive covered airway stent loaded with iodine-125 (125I)-exposed seeds in the healthy beagle dogs prior to clinical application.Materials and MethodsForty-eight self-expandable, radioactive covered airway stents loaded with 125I-exposed seeds were perorally placed in the trachea of 48 healthy beagle dogs under fluoroscopic guidance, which were randomly divided into 4 groups based on the radioactivity (0 mCi, 0.3 mCi, 0.6 mCi, and 0.9mCi). The estimated radiation dose was calculated using the isotropic point source approximation. Radiological follow-up examinations and histopathological examinations of stented tracheal segments and their adjacent organs and tissues were performed at 2, 4, 8, and 16 weeks following the stenting.ResultsAll stents were successfully deployed in the targeted tracheal segment in the beagle dogs without procedure-related deaths. Tracheal diameter stenosis were not associated with the use of radioactive agent. Statistically significant differences in semi-quantitative tracheal injury scores were observed among the groups. The adjacent tissue only showed mild and reversible changes under electron microscope.ConclusionsThis study demonstrates that it is feasible and safety to insert this self-expandable, radioactive airway covered stent loaded with 125I-exposed seeds in the healthy beagle dogs. PurposeThe purpose of this study was to investigate the feasibility and safety of a novel self-expandable, radioactive covered airway stent loaded with iodine-125 (125I)-exposed seeds in the healthy beagle dogs prior to clinical application. The purpose of this study was to investigate the feasibility and safety of a novel self-expandable, radioactive covered airway stent loaded with iodine-125 (125I)-exposed seeds in the healthy beagle dogs prior to clinical application. Materials and MethodsForty-eight self-expandable, radioactive covered airway stents loaded with 125I-exposed seeds were perorally placed in the trachea of 48 healthy beagle dogs under fluoroscopic guidance, which were randomly divided into 4 groups based on the radioactivity (0 mCi, 0.3 mCi, 0.6 mCi, and 0.9mCi). The estimated radiation dose was calculated using the isotropic point source approximation. Radiological follow-up examinations and histopathological examinations of stented tracheal segments and their adjacent organs and tissues were performed at 2, 4, 8, and 16 weeks following the stenting. Forty-eight self-expandable, radioactive covered airway stents loaded with 125I-exposed seeds were perorally placed in the trachea of 48 healthy beagle dogs under fluoroscopic guidance, which were randomly divided into 4 groups based on the radioactivity (0 mCi, 0.3 mCi, 0.6 mCi, and 0.9mCi). The estimated radiation dose was calculated using the isotropic point source approximation. Radiological follow-up examinations and histopathological examinations of stented tracheal segments and their adjacent organs and tissues were performed at 2, 4, 8, and 16 weeks following the stenting. ResultsAll stents were successfully deployed in the targeted tracheal segment in the beagle dogs without procedure-related deaths. Tracheal diameter stenosis were not associated with the use of radioactive agent. Statistically significant differences in semi-quantitative tracheal injury scores were observed among the groups. The adjacent tissue only showed mild and reversible changes under electron microscope. All stents were successfully deployed in the targeted tracheal segment in the beagle dogs without procedure-related deaths. Tracheal diameter stenosis were not associated with the use of radioactive agent. Statistically significant differences in semi-quantitative tracheal injury scores were observed among the groups. The adjacent tissue only showed mild and reversible changes under electron microscope. ConclusionsThis study demonstrates that it is feasible and safety to insert this self-expandable, radioactive airway covered stent loaded with 125I-exposed seeds in the healthy beagle dogs. This study demonstrates that it is feasible and safety to insert this self-expandable, radioactive airway covered stent loaded with 125I-exposed seeds in the healthy beagle dogs.