Abstract
Purpose. To create a model of pharmacokinetics of thyroid-stimulating radiopharmaceuticals (Na131I), to determine the transport constants of thyroid metabolism and excretion by comparing the model results with quantitative radiometric data of patients with thyroid cancer, as well as to calculate the threshold and therapeutic absorbed doses in the thyroid gland on the basis of this model taking into account the effects of ablation. Materials and methods. The principles and methods of pharmacokinetics (compartment simulation), method of Hooke-Jeeves for finding the minimum of function of several variables when determining the values of the parameters of communications between compartments using quantitative data radiometry of the thyroid tissue of five patients entered radiopharmaceutical, methods of calculation of absorbed doses was found through the process of modeling the cumulative activity of the radiopharmaceutical in the thyroid gland. Results. A two-compartment model of the kinetics of a thyroid-stimulating radiopharmaceutical was developed taking into account the radiation damage of thyroid tissue residual after thyroidectomy as a result of internal irradiation during radionuclide therapy. Kinetic curves of changes in radiopharmaceutical activity (time-activity curves) in the model compartments for five patients with thyroid cancer were obtained. On the basis of this model calculations of individual threshold and total absorbed doses in thyroid tissue are carried out. Conclusion. The developed pharmacokinetic model allows to describe the kinetics of radiopharmaceuticals in patients with thyroid cancer. On the Activity-time curves for thyroid tissue there is a characteristic fracture at the time of reaching the threshold dose and then a sharp decline due to the destruction of thyroid tissue as a result of the effects of ablation.
Highlights
Цель работы: создание модели фармакокинетики тиреотропного радиофармпрепарата (Na131I), определение транспортных констант тиреоидного обмена и экскреции при сопоставлении модельных результатов с количественными радиометрическими данными пациентов с раком щитовидной железы (ЩЖ), а также расчет пороговой и лечебной поглощенных доз в ЩЖ на основе данной модели с учетом эффектов абляции
To create a model of pharmacokinetics of thyroid-stimulating radiopharmaceuticals (Na131I), to determine the transport constants of thyroid metabolism and excretion by comparing the model results with quantitative radiometric data of patients with thyroid cancer, as well as to calculate the threshold and therapeutic absorbed doses in the thyroid gland on the basis of this model taking into account the effects of ablation
The principles and methods of pharmacokinetics, method of Hooke-Jeeves for finding the minimum of function of several variables when determining the values of the parameters of communications between compartments using quantitative data radiometry of the thyroid tissue of five patients entered radiopharmaceutical, methods of calculation of absorbed doses was found through the process of modeling the cumulative activity of the radiopharmaceutical in the thyroid gland
Summary
Цель работы: создание модели фармакокинетики тиреотропного радиофармпрепарата (Na131I), определение транспортных констант тиреоидного обмена и экскреции при сопоставлении модельных результатов с количественными радиометрическими данными пациентов с раком щитовидной железы (ЩЖ), а также расчет пороговой и лечебной поглощенных доз в ЩЖ на основе данной модели с учетом эффектов абляции. Материалы и методы: принципы и методы фармакокинетики (камерное моделирование), метод Хука–Дживса для нахождения минимума функции нескольких переменных при определении значений параметров межкамерных коммуникаций с использованием количественных данных радиометрии ткани ЩЖ пяти пациентов с введенным радиофармпрепаратом (РФП), методика расчета поглощенных доз через найденные в процессе моделирования кумулятивные активности РФП в ЩЖ. Результаты: разработана двухкамерная модель кинетики тиреотропного РФП с учетом радиационного повреждения остаточной после тиреоидэктомии ткани ЩЖ в результате внутреннего облучения при радионуклидной терапии.
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