Abstract
Several new formulations of theophylline, loaded on polystyrene beads, were developed. Their sustained release performance was evaluated by in vitro dissolution test. Analog-hybrid simulation was carried out in order to evaluate the influence of some technological parameters on the pharmacokinetics of theophylline. Single- and multiple-phase processes of dissolution were proposed. Furthermore, predicted plasma levels in single- and multiple-dosage-regimen schemes were obtained. Formulations with a first-order release rate constant lower than 1.0 h −1 can be administered as a sustained release dosage form at 12-h intervals.
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