Abstract
Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.
Highlights
Tetracyclines are relatively potent antimalarial drugs with slow/delayed onsets of action [8, 10, 17, 19] and low parasite reduction ratios [20]
The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model
DOX combined with quinine is indicated for standby emergency treatment of falciparum malaria [22], and DOX has demonstrated efficacy in combination with artesunate, albeit with a 20% recrudescence rate that was attributed to an inadequate dosage of one or both drugs [13]
Summary
Tetracyclines are relatively potent antimalarial drugs with slow/delayed onsets of action [8, 10, 17, 19] and low parasite reduction ratios [20]. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Despite the limited clinical role, in vitro and animal investigations have shown that DOX and other tetracyclines are effective antimalarial drugs against drug-resistant parasite strains [4, 10, 12].
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