Abstract
The study was designed to investigate the cardioprotective effect of different combination of Silymarin and Quercetin against Cyclophosphamide induced cardiotoxicity in experimental rats . The Albino rats of either sex were divi ded into five groups of six animals . Group 1 and group 2 served as normal and control group respectively . Other groups treated with Silymarin ( 60 mg / kg, p . o . ) alone, high ( 30 mg / kg, p . o . ) and low ( 15 mg / kg, p . o . ) dose of Silymarin combined with Quercetin ( 10 mg / kg, p . o .). Myocardial damage was induced by the administration of Cyclophosphamide ( 200mg / kg, i . p . ) on the first day and the treatment was conducted for ten days . Twenty - four hours after the last administration, the blood was collected by the retro - o rbital puncture method and the serum biomarker level of Lactate Dehydrogenase ( LDH ) , Creatinine Kinase - NAC ( CK - NAC ) , Creatinine Kinase - MB ( CK - MB ) , Aspartate Transaminase ( AST ) , Alanine Transaminase ( ALT ) and Alkaline Phosphatase ( ALP ) in serum were evaluat ed . Electro - cardiograph parameters such as Heart rate, QRS interval, QT segment, PR interval and RR interval also carried out . Compared to the control group all treated group showed significant activity and high and low dose combination group showed profou nd car diac protection compare to the S ilymarin alone . Among the entire groups high dose combination group ( SILLY30 + QUE10 ) showed most effective Cardio - protection and was also responsible for the significant improvement in the ECG parameters .
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