Pharmacist Interventions and Medication Adherence of H. Pylori-Infected Patients: A Review of Randomized Controlled Studies

Abstract

The Helicobacter pylori (H. Pylori) eradication regimen challenges patient medication adherence. Pharmacists play an essential role in supporting medication adherence to achieve treatment efficacy. This review aimed to evaluate the effect of pharmaceutical interventions on medication adherence in patients with H. Pylori infection taking eradication regimens. The literature was reviewed using Scopus, ScienceDirect, PubMed, and Google Scholar. Keywords included adherence, pharmacist intervention, H. Pylori, and eradication regimen. We collected original articles published in English from January 2002 to December 2022 describing pharmacist interventions to improve medication adherence in adult patients with H. Pylori infection We assessed adherence rates before and after the intervention. Two independent researchers extracted relevant data for the inclusion criteria and assessed the methodological quality of studies using the Joanna Briggs Institute Critical Appraisal Checklist Tools. A total of 413 articles were retrieved, of which six were eligible for review. The most common pharmacist intervention strategy was a combination of patient education with oral and written information provided. The findings suggest that pharmacist interventions support the improvement of medication adherence and highlight the role of pharmacist interventions in enhancing overall health outcomes. Further studies must assess the long-term effects and clinical outcomes of pharmacist interventions.