PHARMACIST INTERVENTION ON THE INCIDENCE OF DRUG RELATED PROBLEMS IN PATIEN WITH CHRONIC KIDNEY DISEASE IN RSU PKU MUHAMMADIYAH BANTUL

Abstract

<pre>Chronic kidney disease (CKD) is a disease that often appears in various countries. Progressive decline in kidney function in patients with chronic kidney disease can lead to unexpected events from drug use, due to decreased kidney function in excreting the drug and its metabolites in addition to the co-morbidities that often arise. Drug Related Problems (DRPs) is one of the problems that can arise from a treatment. Drug Related Problems (DRPs) in addition to impacting the effectiveness and safety of a treatment can also cause morbidity, mortality and treatment costs incurred by the patient. This study aims to look at the picture of DRPs that occur in CKD patients and the effect of pharmacist intervention on DRPs in PKU Muhammadiyah Hospital Bantul by comparing DRPs that arise before and after pharmacist intervention. This research is descriptive with an observational cohort design. Data was collected prospectively in a cohort to see DRPs drawings and the influence of pharmacist interventions on the incidence of DRPs in inpatient CKD patients at PKU Muhammadiyah Hospital in Bantul in the period August-October 2017. The DRPs category followed the PCNE V7.0 DRP classification, recorded DRPs in the problem category for 19 cases (45.2%) and the category of loading were 24 cases (57.1%). The most drug related problems were found to be non-optimal therapy (28.6%), the time / interval of drug administration (26.8%), the combination of drugs with drugs (16.7%) and there were indications of no drugs (11.9% ). Pharmacists intervened with the incidence of DRPs found, pharmacists intervened in the form of changing instructions for using drugs (30.7%), giving information / recommendations to prescribers (16.7%) and providing education to patients (11.9%). Pharmacist intervention can prevent or overcome the DRPs found. Conclusions in this study there are still DRPs that occur in inpatient CKD patients. The involvement of pharmacists can prevent or reduce the incidence of DRPs and ensure efficient, effective and safe drug therapy.</pre>