Abstract
The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
Highlights
The monohydrate form of the neurotransmitter c-amino butyric acid (GABA) has been crystallised in the 0.4–0.8 GPa pressure range, recovered to ambient pressure and used as a seed
Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures
g-Amino butyric acid (GABA) exists as a neutral molecule exhibiting extensive conformational flexibility in the gas phase[5] and can exist as a zwitterion (Fig. 1) or a cation in solution and in the solid state
Summary
Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate†‡ The monohydrate form of the neurotransmitter c-amino butyric acid (GABA) has been crystallised in the 0.4–0.8 GPa pressure range, recovered to ambient pressure and used as a seed.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
