Pharmaceutical Applications for MANNITOL: An Overview

Abstract

This compound belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group. Mannitol is one of the most abundant energy and carbon storage molecules in nature, produced by a plethora of organisms, including bacteria, yeasts, fungi, algae, lichens, and many plants. Mannitol can be used for the reduction of intracranial pressure and brain mass, to reduce intraocular pressure if this is not achievable by other means, to promote diuresis for acute renal failure to prevent or treat the oliguric phase before irreversible damage, and to promote diuresis to promote excretion of toxic substances, materials, and metabolites. There are also multiple uses of mannitol that are FDA-approved. This activity will highlight the mechanism of action, adverse event profile, pharmacology, monitoring, and relevant interactions of mannitol, pertinent for interprofessional team members in treating patients with conditions where it is of clinical value. Mannitol then constitutes a new solute in the plasma, which increases the tonicity of the plasma. Since mannitol cannot cross the intact blood-brain barrier, the increased tonicity from the mannitol draws water out of the brain parenchyma and into the intravascular space. Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a renal function diagnostic aid.