Abstract
The ability of the pigment epithelium (PE) to phagocytize polystyrene spheres, native Sarcina subflava and a mixture of these two particles was studied at short time intervals following injection into the subretinal space in Rana pipiens tadpoles. Polystyrene spheres were interiorized as quickly as 30 min following injection and by 3 hr polystyrene spheres were found throughout the cytoplasm of the PE cells. Sarcina subflava when presented alone were not phagocytized at any interval studied up to 24 hr post injection. Following presentation of the mixed suspension of bacteria and polystyrene spheres large numbers of bead profiles were present within the PE cells indicating that the PE is active phagocytically in the presence of the micrococcus. Occasionally mixed phagosomes containing polystyrene spheres and Sarcina subflava were observed, though the overwhelming majority of the experimental phagosomes contained only polystyrene spheres. These results indicate that the nature of the material presented to the PE can determine whether or not that material will be phagocytized.
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