Abstract
In Rana pipiens embryos, tadpoles, and frogs, the ability of the retinal pigment epithelium (PE) to phagocytize polystyrene spheres was evaluated. Test spheres were injected into the space bounded by the retina and PE. Eyes were recovered at several intervals after injection, and the location of the beads was determined. The PE in each of the stages studied contained numerous bead profiles indicating the active uptake of the test material by this tissue. Bead profiles were not observed in the adjacent retina. In the embryo, the ingested polystyrene was toxic to the PE causing fragmentation of the endoplasmic reticulum and disruption of the mitochondria whereas in the PE of the tadpole and frog no toxicity to polystyrene was noted. Interaction between lysosomes and the polystyrene spheres was observed in each stage examined suggesting an attempt to degrade these ingested particles.
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