Abstract
pH-sensitive poly(methacrylic acid)-block-hydroxyl-terminated polybutadiene-block-poly(methacrylic acid) block copolymers were synthesized by atom transfer radical polymerization of t-butyl methacrylate and follow-up acidolysis. The copolymers can spontaneously assemble into stable and nearly spherical micelle aggregates in aqueous solution, with hydrodynamic diameters (D h ) from 51 to 92 nm and critical micelle concentration of 3.90–7.76 mg L−1. Zeta potentials were found to be increased with increasing (monomer)/(initiator) molar ratios. A pH-dependent phase behavior is produced at approximately 5.4–5.6, as determined by D h and I 335/I 332 fluorescence intensity ratios. The in vitro camptothecin (CPT) release was compositional and pH dependent, and the cumulative CPT release below pH 7.2 was higher than that in pH 7.4. They could inhibit the premature burst CPT release. The copolymer micelles were low in cytotoxicity even at a micellar concentration of 800 mg L−1, and therefore they may be used as potential drug-delivery carriers.
Published Version
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