PGRMC1 can increase progestogen induced proliferation of breast cancer cells: comparing sequential vs. continuous combination with estradiol

Abstract

Objective: Menopausal hormone therapy (MHT) can be performed using sequential or continuous combined regimens. Comparing in-vitro the proliferation of breast cancer cells using these different regimens could lead to suggestions if there may be a different risk of breast cancer which until now is not known. In addition, the aim also was to further investigate the importance of PGRMC1 for hormone induced proliferation using T47D breast cancer cells. This cell line recently has been recommended for breast cancer research.