PGE 2 and PGF 2α in the nasal lavage fluid from healthy subjects: Methodological aspects

Abstract

Prostaglandins E 2 and F 2α were estimated in nasal secretions from ten healthy volunteers by high performance liquid chromatography and radioimmunological assay. Prostaglandin concentrations determined in five consecutive nasal washes with saline at room temperature showed that the nasal mucosa was stimulated after instillation. A substantial increase of basal levels was associated with the second nasal lavage. In all volunteers aspirin treatment inhibited prostaglandin release.