Abstract
PET-MR is increasingly used in a range of clinical indications, though its use for quantitative brain PET research has not been widely reported. To isolate and evaluate MR-based attenuation correction (MR-AC) effects on fitted PET kinetic model parameters, we used a previously reported atlas-based method to synthesize CTs from structural MR scans, substituted for the CTs acquired in a dynamic PET-CT study where [11C]Cimbi-36 was used to quantify 5-HT2 A receptor binding in the brain. The resulting small differences (<5%) in kinetic outcome measures using MR-AC compared to CT-AC were consistent with the observed differences between the MR-AC and CT attenuation maps and within the test-retest variability of the radioligand. This supports the use of MR-AC for quantitative PET imaging of the brain.
Published Version
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