Abstract
In this review, we outline the different etiologies of osteoporosis in the oncologic setting and describe the basis for using PET/CT as screening tool for osteoporosis with a focus on the radiotracers [18F]FDG and [18F]NaF. Osteoporosis is a condition commonly affecting cancer patients due to their age, cancer-specific treatment agents, and effects of cancer. In terms of the unifying mechanism, decreased ratio of osteoblast-bone formation to osteoclast-bone resorption is responsible for causing osteoporosis. PET/CT, a crucial metabolic imaging modality in the oncologic imaging, could be a useful tool for the opportunistic screening of osteoporosis. There are two approaches with which osteoporosis could be identified with PET/CT-using either the (1) CT- based or (2) PET- based approaches. While the CT-based approach has been used with [18F]FDG PET/CT, both CT- and PET-based approaches can be employed with [18F]NaF-PET/CT as [18F]NaF is a radiotracer specific for osteoblast activity.
Published Version
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