Abstract
Three labdane-type diterpenes, namely coronalactoside I, hedychilactone A, and (E)-labda-8(17),12-dien-15(16)-olide, along with the flavonoid glycoside Isolinariin A, were isolated from Heydichium coronarium. Structural elucidation employed spectroscopic techniques (IR, MS, NMR, and DEPT) and comparison with literature data. Pesticidal and antimicrobial activities were assessed. Isolinariin A exhibited potent nematicidal activity (71.33% mortality) against Meloidogyne incognita, while Coronalactoside I demonstrated strong inhibition of nematode egg hatchability (26.00% at 1 µg/mL). In insecticidal activity against Spodoptera litura, (E)-labda-8(17),12-dien-15(16)-olide displayed significant mortality (93.66% at 100 µg/mL). Molecular docking studies indicated favourable interactions with target proteins, suggesting potential in pest management. These findings propose the application of these compounds to mitigate the ecological impact of synthetic pesticides.
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