Abstract
The translation of the achievements from basic science into everyday clinical practice remains an important issue in contemporary health, and is addressed through the new subject of translational research, which aims to bridge the gap between basic research and its application in health. At first, it connected bench (basic) to bed research (clinical applications), which is also known as benchside-to-bedside research. The definition of translational research has evolved over time, ceasing to be a field linked to clinical research, with perspectives that were mainly focused on the development of new health technologies.
Highlights
There is an emerging consensus on four perspectives that comprise different stages of translational research in their broad scope based on their different purposes
In order to move forward in this direction, translational research has broadened its scope and built connections to align itself with the translation of knowledge. It is defined as a systematic and transparent process of synthesis, dissemination, exchange, and ethical application of knowledge to improve results and strengthen public policies and health systems, as well as population health, encompassing all the phases in between production and effective application of scientific knowledge, in its various modalities and epistemological and methodological perspectives, in order to support more beneficial results for society. Universal health systems, such as the Brazilian Unified Health System (SUS), which are complex in their governance, financing, service provision, and implementation arrangements, face numerous challenges so that advances in both in the field of translational research and translation of knowledge are consolidated
If the barriers to translational research are related to the availability and efficient allocation of financial, technical, and political resources for continued and sustainable development, translation of knowledge faces organizational gaps to effectively support the incorporation of the scientific knowledge available for decision-making processes of public health policies, in their stages of formulation, implementation, and evaluation, in a systematic and transparent manner
Summary
There is an emerging consensus on four perspectives that comprise different stages of translational research in their broad scope based on their different purposes. Universidade de Brasília (UnB) – Brasília (DF), Brasil.
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