Perspectives on cellular senescence and short term dietary restriction in adults.

James L Kirkland

doi:10.18632/aging.100204

Abstract

Perspectives on cellular senescence and short term dietary restriction in adults.

Highlights

In an important study in this journal, Wang et al found short term dietary restriction in middle-aged mice is associated with decreased abundance of senescent cells in the liver and intestine [1]
Does short term caloric restriction reduce the proportion of senescent cells in other tissues, such as fat? Obesity, aging, and other conditions are associated with extensive accumulation of senescent cells in fat tissue of rodents as well as humans, in whom fat is frequently the most abundant tissue in the body [2,3,4]
If sufficient baseline cellular senescence is evident in ad libitum-fed subjects in accessible tissues from subjects in current human trials of short term caloric restriction, it may be informative to determine if decreases in cellular senescence occur in the calorically restricted subjects

Summary

Introduction

In an important study in this journal, Wang et al found short term dietary restriction in middle-aged mice is associated with decreased abundance of senescent cells in the liver (centrilobular hepatocytes) and intestine (crypt enterocytes) [1]. Does short term caloric restriction reduce the proportion of senescent cells in other tissues, such as fat? Fat tissue is among the first tissues to be affected structurally and metabolically by caloric restriction, so determining the impact of short term caloric restriction on fat tissue cellular senescence is important.

Results

Conclusion