Abstract
Perspectives on cellular senescence and short term dietary restriction in adults
Highlights
Recent evidence supports the contention that cellular senescence is associated with, and may even be a cause of age-related functional impairment
Cellular senescence causes a variety of cell types to acquire a pro-inflammatory secretory phenotype that produce a variety of cytokines, chemokines, and extracellular matrix remodeling proteases that are associated with tissue destruction [2,3,4,5]
Engineered deposition of senescent cells in a single organ, skin, can cause functional impairments in multiple organs similar to those occurring with aging [8]
Summary
Recent evidence supports the contention that cellular senescence is associated with, and may even be a cause of age-related functional impairment. In an important study in this journal, Wang et al found short term dietary restriction in middle-aged mice is associated with decreased abundance of senescent cells in the liver (centrilobular hepatocytes) and intestine (crypt enterocytes) [13]. The relatively short period of caloric restriction resulted in a 3.3 to 6.5% decrease in senescent cell abundance as a function of total cell number.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
